What is the relationship between MT 2 and hunger?

What is the relationship between MT 2 and hunger?

Melanotan 2 is a melanotropin analog of the natural alpha melanocyte stimulating hormone that is created and communicated via the brain through the skin. The synthetic version of the natural alpha melanocyte hormones travels through the same pathways the synthetic version does. The peptide is available in peptide shops in a freeze-dried version or lyophilized, sterile and ready for research. It is imperative to note that the Melanotan molecule has enhanced bioavailability when it is administered through injection and not any other means. Studies reveal that the peptide binds to the melanocortin receptors. The receptors are essential in influencing skin pigmentation or tanning, energy homeostasis, sexual function and appetite. Melanotan 2 is small and more potent because it targets the M-I receptors the, some of which compete along other melanocortin receptors for the same binding sites.

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Induction of Leptin Generation

Leptin is a hormone that regulates the feeling of hunger. The mechanism of action is actually unknown, however scientists are conducting further investigations to determine the efficacy, and how the hormone can be used to produce new medical products. Leptin and melanocortin affect brain areas associated with hunger and metabolism. The discovery has led to a new dimension in physiology and research with most scientists indicating that further studies reveal that the peptide can be linked to inducing a feeling of hunger.

Leptin is synthesized from fat cells. The cells control the level of energy consumption and food intake. In most cases, the process is mediated by neurons referred as POMC or proopiomelanocortin neurons in the central nervous system. When these neurons are stimulated, a feeling of satiety is induced and as time goes by some people lose sensitivity to peptide. The inability to detect the peptide will lead to lack of sensitivity to the feeling of satiety. This is the main cause of obesity because the person will continue eating even when he or she has reached the required limit.

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Research on test animals indicate that the melanocortin receptor is a product of alpha melanocyte stimulating hormone and the hormone is important in inducing fat storage and feeling of hunger. The activation of the Melanotan 2 by the MC4R receptor increases the amount of food taken by guinea pigs. Animals where the peptide is deficient tend to consume feeds with high fat content and the study shows that the animals without the hormone will consume 90% of the fatty food than the rodents with the receptor.

The administration of leptin via the nervous pathway induces a high consumption of food by the rodents. The alpha melanocyte-stimulating hormone is an analog of the synthetic peptide. In this context, it gives a negative feedback to the mechanism. When leptin is administered the signaling of the melanocortin receptors and the levels of melanocortin in the system increases considerably. Further studies are still underway to find the most effective way of using the hormone to cure some ailments. The peptide offers numerous benefits that can be manipulated to give a good scientific progression.

 

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